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US Critical Illness and Injury Trials Group (USCIITG)

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 2008 Projects and Code-of-Conduct
 
One of the missions of the USCIIT Group is fostering investigator-initiated clinical trials.  To this end, a mechanism was established to solicit clinical proposals with the goal of supporting a number of Clinical Projects annually (see the "Clinical Proposals" tab for additional details).  The success of these efforts depends upon a cooperative model of information exchange.  The approach is inclusive and aims to learn from all those who advocate for the critically ill or injured.  Hypotheses will be tested by multidisciplinary “teams” that openly solicit input and encourage collaboration among investigators with similar ideas across institutions.  As many of these ideas will be novel and exciting, there is an inherent risk in sharing them.  Thus, the USCIIT Group Code-of-Conduct relies on an implicit pact based on an honor system, wherein attendees are expected to:
  • respect the intellectual property presented and the previous commitments made by presenters and discussants
  • disclose competing interests or obligations that may conflict with new or existing Projects
  • refrain from using or sharing privileged information without the consent of the Organizing Committee and the Project Director(s)

 

At the inaugural USCIIT Group meeting in November 2008, 18 clinical projects were presented and discussed:

 

1. Estrogen and flutamide as adjuncts for the treatment of trauma

Irshad Chaudry, PhD

University of Alabama at Birmingham

 

2. Peri-operative Use of MethylPrednisolone (PUMP) study. Effect of Peri-operative methylprednisolone on outcome from cardiopulmonary bypass in children undergoing surgery for congenital heart disease

Paul Checchia, MD

Washington University in St. Louis

 

3. Development of a leukocyte gene expression profiling diagnostic test to predict multi-organ dysfunction after heart failure surgery

Mario Deng, MD

Columbia University

 

4. Controlled study comparing protocol directed tracheostomy decision making with usual care

Bradley Freeman, MD

Washington University in St. Louis

 

5. Identifying patients at risk of acute respiratory distress syndrome (ARDS) in the emergency room: external validation of an ARDS prediction model

Ognjen Gajic, MD

Mayo Clinic

 

6. Disordered sleep, memory and behavior after moderate to severe Traumatic Brain Injury (TBI): Developing a paradigm for treatment

Michael Makley, MD

 

7. Pediatric Trauma Applied Research Network

Randall Burd, MD, PhD

Children's National Medical Center

 

8. Design of a diagnostic tool to predict adverse outcomes in critically ill patients with alcohol and other drug use disorders

Marjolien de Wit, MD

Virginia Commonwealth University

 

9. Validation of Early Bio-Signatures (Biomarkers) for Acute Kidney Injury in Critical Illness and Injury: Creating the Critical Illness and Injury Acute Kidney Injury Collaborative

Gyorgy Frendl, MD, PhD

Brigham and Women's Hospital

 

10. Impact of Dashboards and Checklists on Best Practice Compliance in Critical Care

Henry Mann, PharmD

University of Minnesota

 

11. Validation of a replicable (computerized) protocol for sedation in the ICU

Russell Miller, MD, MPH

Intermountain Medical Center

 

12. Testing the impact of replicable clinical trial methods in critical care research

Alan Morris, MD

Intermountain Medical Center

 

13. A prospective, randomized controlled clinical trial of the doseresponse effects of normal saline or lactated Ringer's solution on intraoperative metabolic acid-base status

Edward Omron, MD, MPH

Ingham Regional Medical Center

 

14. Phase I diagnostic trial for pathogen responsiveness after severe trauma using a bedside tolllike receptor (TLR) whole blood stimulation assay, gene expression analysis, and genotypes in 5 clinical centers

Marion Schneider, MD

University Ulm

 

15. Critical Illness Outcomes Study (CIOS)

Jonathan Sevransky, MD, MHSJohns

Hopkins University

 

16. Genomic Predictors of Outcome in candidemia

Peter Williamson, MD

University of Illinois at Chicago

 

17. A Randomized Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients: The TOP UP Trial

Paul Wischmeyer, MD

University of Colorado

 

18. Pseudoaneurysm Embolization After Blunt Splenic Injury Trial

Ben Zarzaur, MD, MPH

University of Tennessee